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1.
When you curl into a ball to avoid horrible trauma.
Brandon used Defense Curl when Jimmy was a faygoat
by Lysithix September 19, 2009
 
2.
A normal type Pokemon move used to raise it's defense.
Pokemon Trainer: Sandshrew! Use Defense Curl!

Sandshrew curls itself into a ball...
by He Who Remains Unnamed March 27, 2011