A combination of "definite" and "skills" - ergo, "Def Skillz." Def Skillz can be used sarcastically or seriously.
"I tried to talk my mom into letting me stay up later, so I could sneak out. She saw right through everything and grounded me."

"Dude, you've got Def Skillz."

That was used in a sarcastic manner.
by shredxlemon November 24, 2010

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