Top Definition
A condition of seminal fluid buildup that can lead to impaired judgment, erratic behavior, and an overall malaise that can effect men who have not experienced sexual intercourse over a protracted time frame. While masturbation can alleviate some of the symptoms associated with DSB it serves only as a treatment, not a cure. DSB can only be relieved by interaction with a sexual partner.
Rupert: Man I have so much DSB that I can't concentrate at work.

Charles: DSB? What is that?

Rupert: Deadly Semen Buildup. If I don't have sex soon with something I don't know if I will make it much longer.
by JrWorthy October 23, 2009
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