Top Definition
A normal to mildly attractive looking girl who has spent so much time with a DUFF she has taken on DUFF qualities (i.e. sitting around on her ass all the time, extreme sarcasm, increased appetite, and bitchiness). Occasionally refered to as a DUFF Ass.
"Dude, that girl was pretty nice when I got here, but now she's a total DUFF Associate. I'm gonna bang her friend instead."
by hawker240 October 13, 2006

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