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3. D.U.F.F.
Designated Ugly Fat Friend---Usually hangs around extremely Hot girls and DUFF's usually tend to be girls themselves
Bruh do u see dat D.U.F.F. hangin wit Jennifer
1. D.U.F.F.
An abbreviation for 'Designated Ugly Fat Friend'. Often in many large groups of women (usually adolecents) there will be a D.U.F.F. as a means to look better by comparison.
I only hang out with her becuase I need a D.U.F.F., otherwise, she'd be, so, history.
2. D.U.F.F.
The Designated (/Dumb) Ugly Fat Friend.

The cock-blocking friend of the hot chick you're trying to hook up with, often the target of the wingman.
I was totally in with this chick and then her D.U.F.F. totally cock-blocked me!

-or-

I'll take her, while you distract her D.U.F.F.!
4. D.U.F.F.
D-dumb
U-ugly
F-fat
F-friend

or

D-dumb
U-unreasonable
F-fuck
F-face

Go with it as you wish.
Snooki: "Oh my God. What a D.U.F.F.!"
Deena: "I know, right? Totally a duff."
5. D.U.F.F.
1. Dumb Ugly Fat Fuck
2. Designated Ugly Fat Friend (the less harsh defintion)
That we-gotta-go-girl is such a D.U.F.F.
6. D.U.F.F.
Dumb Ugly Fat Friend.
Damn that bitch is a D.U.F.F. Damn your sister's hot, and who's the DUFF?
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