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This is a term used to describe the misfortune that is bestowed on those who date a girl whose name starts with the "kuh" sound whether the actual name starts with a "C" or a "K".
Examples: Kim, Christy, Christyana, Kasey, Karlie, Kate, Katie, Corey, Crystal ....

Jim: "Hey Dave. What happened to all your money and your car... and why is your hair turning gray? And it looks like you've lost weight."

Dave: "I've been dating this girl Kasandra."

Jim: "Say no more. ... Curse of the Kuh."
by Hevea brasiliensis January 14, 2011