Top Definition
When a person has beef with another person, from another area, For example John Queens, NY and Mike Bed-Stuy, NY Then the beef takes place across town.
Mos: Whats Up Medina, Who givin' you static

Medina: Some fool from West

Mos: Word Up! Crosstown Beef
by Cool Wayne April 10, 2007
7 Words related to Crosstown Beef

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