Top definition
- a Constitutional tool that Congress uses to control states, and eventually you.
"Aw man, I can't believe I'm not allowed to grow my own marijuana for medicinal use - even though it's legal in my state - without the Feds busting in and seizing my shit. Damn you Commerce Clause!"

"Tell me about it. I can't segregate races in my hotels and restaurants anymore. Damn you Commerce Clause!"
by Big Freeze UFL February 03, 2010
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