Top Definition
cobra= lashing out poisonous mammal, ambushful and unpredictable.

oprah= powerful female.

cobra + oprah = a powerful poisonous female mammal that lashes out on contact.

synonymous with "bitch" , "crazy woman", or " your mother in law"
As in

"boy don't make me go cobra oprah on yo ass!!!"

"ooooooo babyyy, that girl got some cobra oprah in her step, mmmmmmhmmm make a grown man cry"

"I left that bitch tomorrow she too cobra oprah fo me, ya on level?"
by couturegirl08 April 11, 2010

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