Where a person (usually a guy) is barely worth attention with his glasses on, but when he takes them off you notice how very hot and attractive he is.
(sees guy without his glasses)
Girl 1: OMFG! Where are you glasses?!
Guy: I got contacts.
Girl 1: Aha..... (distracted)
Girl 2: (whispers) Clark Kent Syndrome.
Girl 1: Yeah, totally....
Girl 1: OMFG! Where are you glasses?!
Guy: I got contacts.
Girl 1: Aha..... (distracted)
Girl 2: (whispers) Clark Kent Syndrome.
Girl 1: Yeah, totally....
by 1mad_scientist December 1, 2009
Based off Superman, it's the inability to notice that someone wearing glasses and that person not wearing glasses are the same person.
Kyle: Tim? Is that you?
Tim: Yeah.
Kyle: Oh. I almost didn't notice you with your glasses on.
Tim: Yep. That's Clark Kent Syndrome for you.
Tim: Yeah.
Kyle: Oh. I almost didn't notice you with your glasses on.
Tim: Yep. That's Clark Kent Syndrome for you.
by Rommer711 August 25, 2010