This is when a man while shaking your one hand also grabs and shakes your dick and balls with his other hand.
I was at Tilden the other night and this guy gave me a Cincinnati Handshake. I said "it's time to go" and we all left.
by DJRanderson December 21, 2015
Possibly the most painful experience without leaving second base. Dating back to terribly cold Ohio winters, this manuever was thought up to keep the blood flowing. More often than not, when done incorrectly the Cincinnati Handshake can cause severe bleeding.
My overzealous doctor accidently gave me a Cincinnati Handshake during my physical, I still can't piss straight.
by Still_hobbling_from_the_pain October 11, 2011