Top Definition
Something you get when you stick your hand in a bag of cheese related snacks too many times.
"Dude, I got cheese knuckles from eating that bag of Cheetos"
by A, Smith March 07, 2009
1 more definition
Like a moose knuckle except it has the overwhelming odour of rancid cheese.
Man, I can smell that cheese knuckle from 6 feet away.
by ritwil July 20, 2011

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