Top Definition
Named after the character from Beverly Hills 90210, it is when a girl best friend falls for her male best friend, knowing there is no chance at all for it to be anything more than just platonic. Like Andrea Zuckerman and Brandon Walsh.
I can't beleive I like Joe, I seriously have Brandon Walsh Syndrome.

Ex. Did you see Mary, she is always with Ben, she seriously must have Brandon Walsh Syndrome.
by heartmonkey February 20, 2009
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