Top Definition
When a show goes from being an awesome show online to a piece of shit on TV.
Fred used to be an okay show before it got movies on Nickelodeon. It's a victim of Annoying Orange Syndrome.
by MechanicalDoom June 21, 2014
When an individual has absolutely no social skills and irritates people in their company with one stupid joke after another.
Dude, I can't stop making stupid puns. I think I suffer from annoying orange syndrome.
by I Love Ellie Elephant June 24, 2016
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