Fucked up beyond all recognition, completely unsalvageable, pretty much the worst shit ever.
"I'd like to brew another batch of hefeweizen, but the chick at the plant keeps sending me this Aidsish yeast..."
Fucked up beyond all recognition, similar to fubar. A condition or situation as severe and undesirable as an incurable disease.
Yo, the crowd coming into the bar after the Dave Matthews show was completely Aidsish.