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Since someone with stomach problems like Crohn's Disease can only sometimes tolerate Advil, taking it will either lead to that person feeling better or explosive diarrhea. The meaning of the phrase is derived from Russian Roulette because you never know which time the Advil will end in explosive diarrhea.
I'm going to play Advil Roulette to make this headache go away.
by crohns kid April 20, 2013