Top Definition
Like the mob word "Stand up guy" A stand up bitch is a endearing term to describe a woman or group women with whom a man acciocate's with and has developed a solid friendship with them.
(DeeJay Don Juan) said right before his debut broadcast on SiriusXm radio...'Yo - I wanna give a shot out to A Stand up bitch All home girls from around my way! You know who you are!' You are A stand up bitch and without A Stand up bitch in my life, I wouldn't be here today. Thank you for all your kind words and support God bless!'
by SpinDriver March 22, 2012

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