4,4'-Difluorobenzophenone (4,4-Difluorobenzophenone; 4 4-Difluorobenzophenone; 4 4'-Difluorobenzophenone) is an intermediate in the synthesis of the polymer PEEK and is also used in the synthesis of Flodafinil (Flmodafinil, Difluoromodafinil), Fladrafinil (Difluoroadrafinil) and Modafiendz (N-Methyl-Flodafinil, N-Methyl-Flmodafinil).
Tony: I synthesized Flodafinil (Flmodafinil) by using 4,4'-Difluorobenzophenone and sodium borohydride in ethanol, then converting the 4,4'-(Difluorophenyl)methanol to 4,4'-(Difluorophenyl)methyl bromide using Hydrobromic acid and Zinc chloride catalyst. Then reacting it with sodium thioglycolate. Then a few more steps and I got Flodafinil.
by CognitiveFuel September 12, 2023