Top Definition
A drinking challenge in which a participant must consume 4 four lokos and a 40 ounce in one day. Advisable to drink 3 four lokos early in the afternoon and then the last four loko and the 40 ounce at night after a meal and a nap.
John: "Hey I think I am going do a 4 four 40 next week"

Mike: "I will make sure they have a liver transplant ready"
by AM Fox July 01, 2010

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