Top Definition
To be on one to the extreme, due to the effects of drinking 4Loko specifically, or any potent, high powered malt liquor beverage in general (ie; St. Ides, Old English, etc...).
"Did you see that foo in da club las' nite? Was he on one or what?"

"On one? Shiiit... That nigga was more than on one, he was 4 Lok'd da fuk out!"
by Popi Morenito February 28, 2010

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