1. in reference to how one twists the pickle while smoking meth
"How do i do this?"

"10 to 2 nigga, twist it!"
by SwitchBlade May 29, 2006
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The last ten minutes before most of the clubs shut. This is when deperate lonely chumps get off their asses and hit the dance floor seeking easy prey for their sexual needs. During this short period it is not rare to see desperate males going beyond the "2 above - 2 below" points rule that is generally accepted.
Chump 1: "10 to 2 bois! Let's get some pussy on the go!"

Chump 2: "That bird is a 10 to 2 at best."
by Jandy May 5, 2008
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A way to tell people to chill TFO when they're getting to annoying. Like when they're being extra to the point where your nonexistent gag reflex is acting up because of this person's personality.
Hoe #1: *screaming and jumping on tables*
Real G: Hoe 10 to 2.
by LianneLaHatahs March 20, 2016
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Is the old way that new drivers were instructed (before the airbag advent) to place their hand at the steering wheel. I.e.: The left hand in "10" (clock position) and the right in position of "2".
Instructor: "Once you had the engine working, engage the first gear, and drive with your hands 10 and 2."
by Tiozão October 8, 2015
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She/He was a 10 at 2. This means the girl/guy you would have never talked to at the begining of the night has made it into your life by the time the bar closes at 2am. By rating her on a scale of 1-10 due to the alchol she/he has became a 10 at 2.
Guy 1: Hey man did you see that girl i hooked up with on saturday?

Guy2: Yeah man saw her at the begining of the night, She must have been a 10 at 2.

Guy1: Yeah lets just keep her a secret.
by zmoney12 May 1, 2009
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10 and 2 is the rotation of smoking a methamphetamine pipe, but only while it is in someone’s butt.
Yo, you tryna do 10 and 2 tonight?
HELL YEAH I’m tryna do 10 and 2!
by Gang gang 123444444 August 14, 2019
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