To take part in sexual activities such as masturbation or to have sex with another person. Shizzle meaning "having sex" and nizzle being the vagina or penis etc.
"Go Shizzle the Nizzle"
or
"Shizzle my Nizzle"

8===D (0)
by IDKbecauseREASONS December 9, 2015
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1.) The good dope.
2.) Code word for an illegal substance.

3.) when something is the best of its class.
1.) I got that shizzle bop!
2.) Yo, you got the shizzle bop?
3.) My new car is the shizzle bop!
by Arty Barnes October 2, 2015
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What you say to your friend John when you agree with him
John- "My name is Steve"
Steve- "Fo Shizzle Steve"
by The_UrbanXx_Pro April 25, 2016
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Of course my African American comrad.

A stupid, meaningless phrase that idiotic adolescents use to not offend an african american man to the point that they beat them up.

Stupid
African American Man: Can we go to the fair?
imbecil: Fo' Shizzle my nizzle
by Chesky March 30, 2015
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meaning "for shit my nigga"
this is often said by snoop dogg, aka my daddy.
"you got weed?" "fo shizzle my nizzle"
by confusedspiders January 9, 2017
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I agree with you whole heartedly, my subsaharan brother.
Jimmy asks you to get him a gat. You say “Fo Shizzle My Nizzle.”
by Bobasaursquared April 19, 2020
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