A somewhat derogatory nickname for the much-maligned English town Slough (pronounced Sla-ow), of which sluff is a possible mispronounciation.
"If I had the wings of a sparrow
If I had the arse of a crow
I'd fly over Sluff Town tomorrow
and shit on the bastards below" (football song)

"If you jump off at Maidenhead you can get the train to Sluff."
by Billy-Bob McSanchez April 6, 2005
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A girl/woman who is a whore or slut. One who does not care for personal well being of vagina. Dirty girl.
"Kate is such a sluff. You shouldn't date her".
"Did you hear about that sluff over there. I heard she gave a blumpkin to John"!
by Alupp October 18, 2020
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The act of defense in lacrosse moving towards the goalie after following the guy with the ball out of the box.
by Lax goalie May 29, 2019
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A word to describe a
Stupid
Lazy
Ugly
Fat
Friend
Goddamn seth kaedan is such a sluff today, he wouldn't pick me up to go get my weed!
by Marissa6969 August 15, 2017
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a slut that doesnt fuck;a person that leads you on and doesnt fuck.
Matt says: "Hey justin, Jenni is such a fuckin sluff.!
Justin says: "HaHaHa","true that"
Jenni says: "nothin"
by matthew wuensch November 18, 2007
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vaginal secretions of the sexually aroused female
"When that fish scent fills the air,
there'll be sluff juice everywhere" -- Wang Dang Doodle
by Weak Thought October 12, 2010
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Person who does little to nothing at work.
He has been Sluff Ass'in around all day.

She is a real sluff ass.
by Quartermaster May 6, 2009
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