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game over 

when u have lost the game usally runing out of lives.
last guy danm i died
GAME OVER
game over by bob December 8, 2003

game over 

when youre trying to holler at a girl but you do something to totally ruin your game
i approach sandy with a drink in hand and end up tripping and spilling half the drink on her shirt.. my friends greet me with a "game over" when i return
game over by bay resident December 28, 2005

game over 

When you beat someone in any type of situation. Also an exclaimation when you beat the shit out of some asshole. Or when a situation is just outta hand and you don't want to deal with it anymore.
Give it up bitch, game over.
GAME OVER MOTHER FUCKER!
This is game over for me, I'm out.
game over by grrrinator October 27, 2004

game over 

Phrase used to describe one who has consumed far too much liquor and is therefore reduced to a drooling, snoring, unconcious lump who may or may not end up vomiting on themselves or other people later on in the evening. May sometimes lead to boot and rally, pissing in the fridge, or other drunken acts which will undoubtedly not be remembered in the morning. See ptfo. This is the most opportune time to attempt such daring feats such as teabagging, giving a flying squirrel or other humiliating acts.
Dude, check nick out, Game over.
Woah, did nick just boot-n-rally? i thought it was game over! add another tick to the boot-n-rally tally.
game over by Ry-Lo October 1, 2007

Game Over 

1.Something that is Over.
2. A situration that is lost.
3.Nothing left to do.
Man! I lost the match Game Over.
His wife just caught him cheatin."Game Over"
Game Over by DE-BO July 5, 2004

game over 

when the act of slipping or falling results in fatal or severe bodily harm
dude my brother had a game over in the shower.
omg how?
he totally slipped on the soap and broke his leg.
game over by NRHsteezy March 4, 2008