Acronym (Slang) for "I'm Out" when conversing using the Microsoft Communicator Software. v. The act of hastily departing an online collaboration session with little notice to others participating in the dialogue.

I am no longer part of this conversation as it is digressing rapidly; it will inevitably over-step that invisible moral line in the sand that uniquely distinguishes the employed from the homeless.
<message>
"Dude, I wanna dip it in the new workstudy sittin in the corner desk..."
<reply>
"IO"
<end of converstion>
by Big G Funk November 3, 2008
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doctor: you have cancer
patient: oh no
doctor: to be specific,you have cancer.io
patient: *fucking dies*
by gearworks June 17, 2018
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IO

Instant Orgasm, used by girls to describe something they find attractive and or hot.
"Wow! that sports car is cool." "Yeah! its a total IO."
by aussieslang101 November 12, 2009
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The lecture is on Tue io Thu.

OR (it may be used with dots)

I bought some bananas i.o. apples.
by veekadikoydegskupayialiyor December 31, 2013
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Daniel: "Your Craigslist buyer backed out..."
Marianne: "IO."
by mabmoney June 9, 2015
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Jovian moon that orbits around the planet Jupiter.
by u.ber. August 22, 2003
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