toothpaste hangover Share definition Flag The effect that makes everything taste disgusting after you brush your teeth. Augh! This orange juice tastes horrible, thanks to that gosh-darned toothpaste hangover! toothpaste hangover by Yoda Pez June 14, 2011 0 0 Get merch Get the toothpaste hangover mug. Buy Now — $32.95 See more merch