Runzler Share definition Flag The act of screwing up something that really shouldn't and/or can't be screwed up. Why did the pitcher swing at that pitch when he could have drawn an easy walk? He totally Runzlered that at bat. Runzler by sallythompson May 7, 2011 0 0 Get merch Get the Runzler mug. Buy Now — $32.95 See more merch