run train 

to "gangbang" a girl with several friends.

Think of an actual train - one goes over the tracks, and then another. Now, say these trains were friends of some asshole, and the tracks were... you get the idea.

run train by babette January 1, 2004

run train 

When a bunch of guys have sex with the same girl one after another with no break for the girl

Yo tonight were going run train on that bitch Jenny
-Cool hopefully i'm not the caboose.

run train by bloddyazzcheese February 14, 2009

run train 

To call your friends to preform various unforgivable acts of a sexual nature on one female in rapid succession.

I'm 'bout to call bovice. We 'bout to run train on you, bitch!

run train by un4gvable1 March 11, 2008

run train 

to have sexual intercourse with a girl, with the help of one's friends.

"Bitch if you don't leave RIGHT NOW me and Bo Vice gonna run train on you!"

run train by mechaduck November 26, 2007

Run Train 

Where men all have sex with one women. Either at the same time or one after another.

Yo don't make me get Chaps cause he'll run train on you!

Run Train by BobCock April 14, 2009

run train 

To do work on multiple people in a game or anything that has competition. IT IS NOT ANYTHING SEXUAL.

Jared: Wanna run train in gears later?
Dave: Yessir!
Jared: Don't invite Sam or else we won't be able to.

run train by Grogdog November 13, 2011

Run Train 

To "do work" on players in Call of Duty: Modern Warfare 2 by shooting them in the face while dual wielding ranger shotguns.

Holy shit! That kid is letting the beat build, he is about to run train on that kid!

Run Train by LetTheBeatBuildBeetch November 15, 2009