Prune Hole Share definition Flag n: The little opening betwixt the ass cheeks wherewith poop comes out. (I.E.- anus, butthole, poop chute.) Dude, my prune hole did not appreciate the exit of the spicy enchiladas I ate last night. Prune Hole by Senor Chefy October 30, 2008 0 0 Get merch Get the Prune Hole mug. Buy Now — $32.95 See more merch