look up any word, like cunt:

1 definition by urworstnitemareagin

 
1.
pfo
acronym for PERMANENTLY FUCKED OFF

meaning if you're pfo'd you are permanently fucked off. aint got nothing coming. you fucked yourself. ;)
you're pfo dude. you crossed the line and there aint no going back.
by urworstnitemareagin April 24, 2011