adj: Pissed off; uppity; aggressively excited; ready to fight (esp. verbally confrontational); irritated; bad attitude in response to something disagreeable. Origin is unknown - but usage was way back in the 1970's (approximately 1974). No - it did not start in some "college" in 2003! Was a well known and used expression decades before that.
"I don't care how you feel about what I said, bitch - don't get all hankty and get your ass kicked!"