a contraction of two words: totally and waisted.
twaisted is short for a situtation when you or someone you have been in contact with have crossed over the line of being drunk, being hammered, or smashed. you or them have become totally waisted.
incapable of standing on their own, speaking without excessive amounts of verbal diahrea
janie was talking so much shit about how she sucked a great dick. she went into the bathroom to prove it and puked all over the guy. man she was twaisted last night
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