Acronym of "No You Stupid Piece of Shit." Little often used because people don't recognize a useful acronym when they see it. Also, they don't see it. Originally coined by Maddox in 1999 on his webpage "The definitive guide to the Internet." Variations include NYSS and No YSPOS.
Cuntnugget: Hey doods u wanna jon my RPG?
Moron: SIGN MY PETITION TO MAKE SOMETHING HAPPEN.
You: No, YSPOS.