When somebody is such a woman that they need to not just man up, but Man The Fuck Up. Can be shortened to MTFU. Usable on both genders and all species. Also, note that someone who gets some supresses the need to have this for a few days as they have already Manned Up enough.
Ed: Wow, it's reallt bright outside :)
Dude: Man Up Ed.
Ed: No, look, it's so bright, lets go and play outside.
Dude: Ed. I'm going to say this just once. Man The Fuck Up!