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Definitions by Teflon Razor Cat

Balls Are Tweeste 

Whenever you are in a bind, or a crappy situation that you cannot get out of, your Balls are tweeste. Imagine if you will, somebody grabbing your testes, and twisting them, there is absolutely nothing you can do.
John missed the plane? His balls are tweeste.

OR

On a scale of 1 to tweeste, John's balls are tweeste.