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2 definitions by Jason_The_Chatfield

The drug emitted from the brain when one is derping on addictive social media sites. The more you derp, the more derpamine is emitted to keep you derping.
While I'm trying to have a conversation with him, Jeremy keeps checking his @'s for another hit of derpamine. What a cunt.
by Jason_The_Chatfield August 28, 2013
The infinite chasm one derps forth all mindless brainfarts that surface at any time of day, blurted while gormlessly holding a smartphone, waiting for something, anything to happen.

-Anything on Twitter, Tumblr, Pinterest, Facebook, Google+,Reddit,Vine or MySpace that is just nothing but pure, mindless, vapid Derp.

(Also spelled "Durpstream", or "D3rpstr33m")
A: "Anything happening on the derpstream?"
B: "Jeremy got engaged and some kid got saved from a dog by a cat"
A: "Sweet" *continues lighting bong*
by Jason_The_Chatfield May 16, 2014