1. A change of condition, idea, status, etc.
2. Your characters' job mode in Final Fantasy XIII during a fight. You can shift it back and forth, depending on what the situation calls for.
1. John: I think it's time for me to have a relational paradigm shift.
Jeff: You do mean get a girlfriend, right?
2. Evan: Ohay, the enemy staggered, time to use the Relentless Assault paradigm! "paradigm shifts*