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It means "Too bad he's gay, you deliberately obtuse dunderfuck."
TT: What does le sign actually mean in this context?

TG: oh come on

TT: Come on what?

TG: LE SIGN IS UNIVERSALLY UNDERSTOOT TO MEAN TOO BAD HES GAY YOU DELIBERABLY OBTUSE DUNDERFUCK
le sign by renegade98 October 7, 2012

roloff sign 

Condition that occurs in men where the scrotum turns a dusky blue or blackish color that is an accurate prognosticator of impending death. This is not to be confused with "blue balls" occurring with sexual frustration. Roloff sign happens after trauma, heart attack, drug overdose, etc. in which the guy is near death (most often seen in a hospital setting). Despite extraordinary measures, roloff sign indicates a poor outcome is likely.
"I can't believe Joe is still alive after that bad car accident."

"Dude, he ain't gonna make it...he's got the roloff sign."
"Damn, that's right, if the balls are blue...you know he's through"
roloff sign by RatchetNurse May 27, 2014

American Sign Language 

A series of hand gestures, each representing a letter of the alphabet or an entire phrase; Very useful to deaf people & also if you're somewhere ya gotta be quiet so you just sign instead of talk. It originated in the early 19th century in the American School for the deaf in Hartford, Connecticut.
Monica's daughter is deaf so I got to see American Sign Language in action. It was a very interesting experience & her siblings knew how to sign too; their fingers just flew!

Yellow Dollar Sign 

The sign that means you've been demonetised. You're gonna get fewer ads and thus less money. Welcome to Hell
YouTuber comment: "I said the word 'pussy' once and I immediately got demonetised?! Wtf?! I work hard on a video only to see that cheeky ass yellow dollar sign beside it. Its laughing at me now!"
Yellow Dollar Sign by Mickey_G_ April 24, 2019

Virtue-signaling 

Virtue-signaling (noun): the self-serving, disingenuous act of presenting & solidifying oneself as concerned with, committed to, or compliant to a specific political alignment regarding political topics or issues for prestige or ego.
If the President genuinely cared about women's rights, he'd do less virtue-signaling on Twitter and more action.

Sign Language 

SIGN language is a debating tactic used by most women and male feminist by engaging in language meant to Shame, Insult, Guilt, and a Need to be right against their opponent when they themselves can’t present a cogent argument based in facts, statistics and/or logic.
Kevin: Today’s modern female wants a traditional male but yet they’re not traditional women. They’re not equipped to be traditional women, they weren’t raised that way, nor do they want to be that way.

Female: Who hurt you? You’re just bitter and you probably have small penis. You obviously hate all women including your mother, and you don’t know what you’re talking about because you’re just a simple man.

Kevin: I’m Red Pilled, and your SIGN Language doesn’t work on me.
Sign Language by MGTOW Black March 9, 2021