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Mos Def comes from two words, mos is short slang for "most" and def is short for "deft" which means skilled. Thus "mos def" is defined as "most skilled."
Mos Def is also a rap alias for one Dante Smith.
mos def by RTK666 December 28, 2004
Related Words
abrieveation of im a deaf old dear
"ima steal your wallet", "she can't hear you dude, she's mos def"
mos def by bencé December 15, 2004
As coined by the legendary rapper himself, "Mos-Def" refers to a thing, person, experience etc which is "mos" (or most, hugely, a lot), "def" (excellent, awesome; NOT short for 'definitely').
Mos-Def's changing his rap name to "Yasiin"?? Don't sweat it, he's still the MOS DEF rapper out.... after Chuck D of course..
Mos-Def by LittleRedFox.com.au September 28, 2011
Short for most Definatly
I mos-def love fries from McDondals
Mos-Def by And the Pickles January 1, 2007

mos def! 

short for most definetly!!!!
tyler: Did it feel the best when i put it in your butt last night?

zane: mos def!
mos def! by jake1234 April 23, 2006
shortened form for 'most definitely'
A: you gonna come out tonight?
B: oh mosdef!
mosdef by AznC June 18, 2003