1 definition by yzed

Top Definition
"The one that got away" or "first love" used in`2010 movie, Hot Tub Time Machine. Only whispered, and in repetition by all friends present.

Most people go their entire lives without finding this one special person, so once you've found your `great white buffalo` .. never let them get away.
"Jenny is your Great White Buffalo. You have to break up with her tonight"

"Kailie Burfield is the Great White Buffalo of many men, she longed for by all .."
by yzed December 29, 2011

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