Originally used in an episode of Family Guy in the end of their 1999 season, by cardinals reading through the bible. Later used by the Simpsons' Homer when he became a missionary. Now, it's just slang for anything from Jesus to shrooms.
"On page ---, it says Jebus, isn't supposed to say Jesus?"
"SAVE ME JEBUS!"
"Sweet Jebus, don't touch me there!"