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beerectile dysfunction 

After you have too many beers, you suddenly can't get it up.
Dude, they need to invent a pill for beerectile dysfunction!

directile dysfunction 

A disability that causes those it afflicts to be unable to follow even the most simple instructions.
Bill: Dude, wtf!?! You were supposed to pick me up at the airport yesterday.

Tom: For realz? I thought that was tomorrow. My directile dysfunction must be acting up again.

direct file dysfunction 

(aka DFD) When a shitty instant messenger file transfer crashes halfway through leaving you empty and unsatisfied.
My MSN has direct file dysfunction.

erectile dysfunction 

Dude my erectile dysfunction means I can OD on Viagara

Hillarectile dysfunction 

An inability to become aroused due to prolonged exposure to Hillary Clinton.
Joe was suffering so bad from Hillarectile dysfunction that even Viagra couldn't help.

textual dysfunction 

The inability to get a thumbs-up during textual intercourse
Murray has tried textagra for his textual dysfunction, to no avial.

Bill was devastated when all his textual advances were met with thumbs-down results.