1 definition by lsdmdma69

Come Up

The time from when you first take a drug, to when you reach the first peak of the trip/roll. Usually the first 30 minutes to 2 hours depending on what drug taken, and the person.

The come up with those rolls was pretty quick.

I always get sort of antsy on the come up with doses.

by lsdmdma69 May 24, 2010