CognitiveFuel's definitions

TP-MeCl

TP-MeCl is ThioPhenyl-Methyl Chloride (or Thiobenzyl chloride, TB-Cl). It is used as an intermediate in the synthesis of TP2P (ThioPhenyl-2-Propanone) through a grignard reaction of Thiophenylmethylmagnesium chloride with acetonitrile and hydrochloric acid work-up. TP-MeCl is made by chloromethylation of Thiophene (TP-H, TPH, Thiophene, Thiophenyl Hydride).

I synthesized TP-MeCl using TP-H and chloromethylation. Then I synthesized TP2P.

by CognitiveFuel August 4, 2023

MDP2NP2

MDP2NP2 is 3,4-MethyleneDioxyPhenyl-2-NitroPropane. 3,4-Methylenedioxyphenyl-2-nitropropane can be obtained by reducing 3,4-MethyleneDioxyPhenyl-2-NitroPropene (MDP2NP) with sodium borohydride in ethanol (methanol won't work because then the sodium borohydride will decompose. The MDP2NP2 (3,4-MethyleneDioxyPhenyl-2-NitroPropane) can then be turned into MDP2P (3,4-MethyleneDioxyPhenyl-2-Propanone) by the Nef reaction. Then it can turn into MDEA (ecstasy) with ethanol and ethylamine aluminum galinstan amalgam reductive amination. MDP2NP2 can also be directly reduced to MDA with aluminum galinstan amalgam.

I produced MDP2NP2 by reducing MDP2NP with sodium borohydride in ethanol.

by CognitiveFuel January 9, 2023

Khat

Khat is a plant with leaves that you chew to get energy and a high. It's relaxing yet stimulating. Khat leaves contain mostly cathine and a little cathinone and it's mostly the cathinone (phenylpropanoneamine, 2-aminopropiophenone) that gives you energy with cathine contributing very little to the energy and the high. Khat is used to study similar to Adderall, Ritalin, Modafinil, and Caffeine. Khat can be chewed freshly picked from the khat tree or brewed into a tea. The leaves must be used quickly, or it will all turn into cathine (phenylpropanolamine, D-Norpseudoephedrine) within 3 days of picking them. Khat is legal in some places like Ethiopia, Yemen, and South Africa, yet illegal in other places like the US and Canada. Khat releases dopamine and norepinephrine. Khat is like Caffeine, but stronger. Khat is Nature's Ritalin. The Khat plant needs less water than the Coffee plant and can withstand higher temperatures than the coffee plant. Khat loves the sunlight.

I picked and brewed fresh khat leaves. It gave me energy to study and do homework and clean. I got a nice high off of khat. Khat is the coffee of the future.

by CognitiveFuel January 8, 2023

Dibutyl ether

Dibutyl ether is an ether that is used for complex grignard reactions where higher temperatures are needed. Dibutyl ether is good for reacting benzyl magnesium chloride (made from benzyl chloride and magnesium turnings in dibutyl ether) with acetonitrile in dibutyl ether at elevated temperatures. Then reacting it with hydrochloric acid to get Phenyl-2-Propanone. Dibutyl ether increases the yield compared to diethyl ether. Dibutyl ether is produced by reacting butanol with sulfuric acid. The temperature cannot be too high, as butanol could dehydrate into butene (1-butene). The ether must be stored with butylated hydroxytoluene as explosive peroxides can form.
Properties
Chemical formula
C8H18O
Molar mass
130.231 g/mol
Appearance
Colorless liquid
Odor
Fruity
Density
0.77 g/cm3 (20 °C)
Melting point
−95 °C (−139 °F; 178 K)
Boiling point
141 °C (286 °F; 414 K)

I reacted benzyl magnesium chloride with acetonitrile in dibutyl ether and hydrolyzed it with hydrochloric acid to get Phenyl-2-Propanone.

by CognitiveFuel January 16, 2023

Thiophene

Thiophene is a chemical that is useful in a lot of stuff. It can be bought or synthesized from butane and sulfer at the vapor phase at 65 °C. Thiophene is an aromatic compound. Thiophene can be chloromethylated by formaldehyde solution and hydrogen chloride at 5 °C or lower to 2-chloromethylthiophene/2-(Chloromethyl)thiophene (TP-MeCl).

Properties
Chemical formula
C4H4S
Molar mass
84.14 g/mol
Appearance
colorless liquid
Density
1.051 g/mL, liquid
Melting point
−38 °C (−36 °F; 235 K)
Boiling point
84 °C (183 °F; 357 K)
Magnetic susceptibility (χ)
-57.38·10−6 cm3/mol
Refractive index (nD)
1.5287
Viscosity
0.8712 cP at 0.2 °C
0.6432 cP at 22.4 °C

Tony: I synthesized 2-chloromethylthiophene from thiophene.

by CognitiveFuel September 11, 2023

2-chloromethylthiophene

2-Chloromethylthiophene is used as an intermediate to 1-(2-thienyl)-2-Propanone.

In a 2-l. beaker surrounded by an ice-salt bath , and fitted with a mechanical stirrer and a thermometer, are placed 420 g. (392 ml., 5 moles) of thiophene and 200 ml. of concentrated hydrochloric acid. A rapid stream of hydrogen chloride is passed continuously into the mixture with vigorous stirring. When the temperature reaches 0°, 500 ml. of 37% formaldehyde solution is added at a rate that will permit the temperature to remain below 5°. The addition requires about 4 hours. When all the formaldehyde solution has been added, the mixture is extracted with three 500-ml. portions of ether. The ether extracts are combined, washed successively with water and saturated sodium bicarbonate solution, and then dried over anhydrous calcium chloride. The solvent is removed by distillation, and the product is distilled under reduced pressure through a 50-cm. fractionating column. The product boiling at 73–75°/17 mm. is collected. The yield is 257–267 g. (40–41%) of a colorless oily liquid.

I synthesized 2-chloromethylthiophene from thiophene, concentrated hydrochloric acid, and formaldehyde.

by CognitiveFuel January 21, 2024

Night owl on steroids

A night owl on steroids is when you stay awake until midnight or later and even until 3am, 4am, or even 5am without feeling sleepy or tired. It's when you're sleeping until 11am, 12pm, or 1pm. You sleep 8 hours and feel refreshed when you wake up around noon or later. You get energized from 5am and even more later. It's delayed sleep phase disorder. The treatment is Modafinil early in the morning to wake up since you can't turn the rest of society into night owls on steroids or even night owls. Treatment also includes taking 25mg to 50mg Amitriptyline at 10pm So that by the time 11pm comes, you fall asleep.

Tony: I have delayed sleep phase disorder. So by taking Modafinil early in the morning, I can wake up early in the morning and stay awake. Then I fall asleep earlier too. I used to be a night owl on steroids. Now I'm an early bird as long as I take Modafinil early.

by CognitiveFuel September 2, 2023