1) Stands for what the fuck is up?

2) A commercial trying to inform people about "Big Tobacco's crazy ways and addictive products"

Running for exercise and picking up trash you find along the way. It's good for the body, mind, soul, and environment! Started in Sweden but is making its way to the U. S.

slang that is used to mean "what the fuck is up?"
is also an anti-tobacco ad capaignhttp://www.whudafxup.com/

The lamest, stupidest, gayest commercials about cigarettes.

a clever way to say "what the fucks up" without actually cursing.

What a F*** up!! ie bonehead