A sarcastic reference to being ugly or deformed. Either used directly or as a lone, out of context reference.

Phrase refers to the film reviews of Plinkett at Red Letter Media, who coined the term when observing an alien character in "The Phantom Menace."
Hey, you in the sweater. What's wrong with your face?
by Endangered February 04, 2010
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What the mechanic at LS Customs says to you, as you roll up in a flaming car with no doors.
*drives to LS customs in a bucket*
Mechanic: "What's wrong with her now?"
by CCW2013 June 05, 2020
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Used (usually in jest) when something is bound to go completely and utterly wrong.
Guy: I'm going to buy some bondage gear for my brother's girlfriend and say it's from him.
Guy's friend: Yeah, what could go wrong, right?
Guy: Exactly!
by SethFalco March 16, 2017
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a phrase usually said after someone says something uncalled for, blatantly disrespectful, or just annoying.

it questions what is wrong with u
Xavier: I love eating brown flamingos
Me: what be wrong
by laybaee September 27, 2021
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