Bro is something you call a "mongrel" or a brother aka your friend... or your greatest enemy if you feel me. But a whatsup means WHAT IS NEW asking your friend/enemy what is new. If a friend, then you are actually asking "whats new" but if its an enemy this jargon is more or less used as a threat as in "whatsup bro, i will tear your spine out you disgusting maniac". People who DO use the term whatsup bro to their friends are deemed mentally and physically insane, and are fit for only one place in this godless world... the highest security mental intitution.
Alex: Whats up bro (to friend)
Carl: Um... not much.... yeah hello police? take this maniac away from me... STAT....

Alex: Whats up bro (to enemy)
Mark: Ahh a challenge.... finally an opponent worthy of my skills.....
by CarlMarx November 24, 2013
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Used in the African-American community as an interrogative.
It can also be used to assure someone that what you said is 100% truthful.
Use #1

Tony: Lil Wayne is better than Biggie.
Chris: Bro what?

Use #2

Tony: I just got paid 600 today.
Chris: You're lying.
Tony: Bro what.
by Ghetto Intellectual July 22, 2016
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Something Chad says to Derek when something crazy is happening
Chad said Derek when Chad got a new stepsister what the fuck bro
by Wolfie the titan February 10, 2021
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when you encounter a rubbish thing and you're like nah bro what is this bro nah bro what is this bro what bro nah bro
"you have to do a 100000 word essay"
"Nah bro, what is this", " bro nah bro what is this bro what bro nah bro""
by BotBot3000 May 02, 2021
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The unwritten rule among men. When a bro confides in another bro about facts, opinions, or other bro things it is not disclosed to the women. Basically a respect of privacy among men.
Andryon: "Yo Steve I think your a lucky dude getting a five women plow session in a single day."
Steve: "Thanks Andryon, but remember, what a bro knows never goes to the hoes."
Andryon: "I gotchu not a word to the women"
by NotAndryon June 24, 2017
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General greating for all occasions. Proper response is "what choo do bro?"
"What cha do bro?"
"What choo do bro?"
by Mr. Newby April 30, 2005
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