Not only to give a shit, or a fuck... but to actually give two shits and a fuck.

Usually used as an expression of sarcasm when you couldn't give any less than you already don't.

When you eat dirt for the first time and leave your family to build a shack in the woods

A enhancement of the popular terms for Two shits, Give a fuck and Give a shit. All of these terms used to describe how much you don't care.

When you tell someone that you could give two shits and a fuck about something you are telling them that you not only don't care, but you are in fact angry that they even wasted precious time in your life by giving you the information that they have told you.

Basically a sarcastic way of telling some one that you really could care less about them and/or anything that is coming out or their mouth.

A reaction to a very unlikable situation that could possibly make or break your life