To irritate or injur a joint/bone.
I was running down the court and my ankle tweaked.
by Idek😂 February 6, 2019
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to tweak someone's ear; to tweak someone's nose.
by Matthews Marc October 6, 2020
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A versatile descriptive word for seeing something creepy, absurd, weird, crazy, etc. Typically used when one is high on cannabis feeling its effects.
"Bro I'm too baked, this movie is tweaking me!"

"That guy in the park is tweak!"
by Robohtman July 30, 2021
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Student on their phone... Mrs.Charlton takes it. She is a tweak
by Tweaked out November 15, 2018
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Someone that is on drugs and acting crazy usually some sort of amphetamine
Yoo john has been acting really tweak lately
by Surrfart October 18, 2017
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Kinley: I accidentally texted Hannah happy birthday today but her birthday is next weak.

Emma: wow you are such a tweak
by huntsville256 May 7, 2019
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When a goof smokes to much dope he a tweak
That nigga z and rat are some fuckin tweaks
by 5th grade trapper September 7, 2021
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