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To drink to the point of extreme intoxication. Synonymous with tie one on.
Eric: I think I'm going to tie one off tonight.
by littlebadger June 19, 2009
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Jun 24 Word of the Day
An exclamation made when your friends or family are teasing you to a point where you can't handle it anymore and a hissy fit is in order.

Derived from a YouTube user's famed outburst following Britney's lackluster performance at the 2007 VMA's.
Sarah: 'OMG Susan, I can't believe you are wearing the same skirt as yesterday. Oh, and by the way, EVERYONE knows what you did with Kevin on the weekend. Plus you look a little fat, are you retaining water?'

Susan: 'LEAVE BRITNEY ALONE!'
by Billy Chickenhole September 15, 2007
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2
to shoot up drugs intravenously
Delina wanted to really "tie one off" so she bought a teener from her dealer.
by aniled June 04, 2009
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